Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study.
Identifieur interne : 000495 ( France/Analysis ); précédent : 000494; suivant : 000496Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study.
Auteurs : Alain Toledano [France] ; Pascal Garaud ; Daniel Serin ; Alain Fourquet ; Jean-Francois Bosset ; Noel Breteau ; Gilles Body ; David Azria ; Olivier Le Floch ; Gilles CalaisSource :
- International journal of radiation oncology, biology, physics [ 0360-3016 ] ; 2006.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Association thérapeutique (), Cyclophosphamide (administration et posologie), Dosimétrie en radiothérapie, Femelle, Fluorouracil (administration et posologie), Humains, Mastectomie partielle, Mitoxantrone (administration et posologie), Pigmentation de la peau, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Récidive tumorale locale, Sujet âgé, Traitement médicamenteux adjuvant, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (radiothérapie), Tumeurs du sein (traitement médicamenteux), Études prospectives.
- MESH :
- administration et posologie : Cyclophosphamide, Fluorouracil, Mitoxantrone.
- anatomopathologie : Tumeurs du sein.
- radiothérapie : Tumeurs du sein.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Adulte, Adulte d'âge moyen, Association thérapeutique, Dosimétrie en radiothérapie, Femelle, Humains, Mastectomie partielle, Pigmentation de la peau, Récidive tumorale locale, Sujet âgé, Traitement médicamenteux adjuvant, Tumeurs du sein, Études prospectives.
English descriptors
- KwdEn :
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Breast Neoplasms (drug therapy), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Chemotherapy, Adjuvant, Combined Modality Therapy (methods), Cyclophosphamide (administration & dosage), Female, Fluorouracil (administration & dosage), Humans, Mastectomy, Segmental, Middle Aged, Mitoxantrone (administration & dosage), Neoplasm Recurrence, Local, Prospective Studies, Radiotherapy Dosage, Skin Pigmentation.
- MESH :
- chemical , administration & dosage : Cyclophosphamide, Fluorouracil, Mitoxantrone.
- drug therapy : Breast Neoplasms.
- methods : Combined Modality Therapy.
- pathology : Breast Neoplasms.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adult, Aged, Chemotherapy, Adjuvant, Female, Humans, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Prospective Studies, Radiotherapy Dosage, Skin Pigmentation.
Abstract
In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies.
DOI: 10.1016/j.ijrobp.2005.12.020
PubMed: 16542788
Affiliations:
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type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Garaud, Pascal" sort="Garaud, Pascal" uniqKey="Garaud P" first="Pascal" last="Garaud">Pascal Garaud</name></author><author><name sortKey="Serin, Daniel" sort="Serin, Daniel" uniqKey="Serin D" first="Daniel" last="Serin">Daniel Serin</name></author><author><name sortKey="Fourquet, Alain" sort="Fourquet, Alain" uniqKey="Fourquet A" first="Alain" last="Fourquet">Alain Fourquet</name></author><author><name sortKey="Bosset, Jean Francois" sort="Bosset, Jean Francois" uniqKey="Bosset J" first="Jean-Francois" last="Bosset">Jean-Francois Bosset</name></author><author><name sortKey="Breteau, Noel" sort="Breteau, Noel" uniqKey="Breteau N" first="Noel" last="Breteau">Noel Breteau</name></author><author><name sortKey="Body, Gilles" sort="Body, Gilles" uniqKey="Body G" first="Gilles" last="Body">Gilles 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(radiotherapy)</term><term>Breast Neoplasms (surgery)</term><term>Chemotherapy, Adjuvant</term><term>Combined Modality Therapy (methods)</term><term>Cyclophosphamide (administration & dosage)</term><term>Female</term><term>Fluorouracil (administration & dosage)</term><term>Humans</term><term>Mastectomy, Segmental</term><term>Middle Aged</term><term>Mitoxantrone (administration & dosage)</term><term>Neoplasm Recurrence, Local</term><term>Prospective Studies</term><term>Radiotherapy Dosage</term><term>Skin Pigmentation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique ()</term><term>Cyclophosphamide (administration et posologie)</term><term>Dosimétrie en radiothérapie</term><term>Femelle</term><term>Fluorouracil (administration et posologie)</term><term>Humains</term><term>Mastectomie partielle</term><term>Mitoxantrone (administration et posologie)</term><term>Pigmentation de la peau</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Traitement médicamenteux adjuvant</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (radiothérapie)</term><term>Tumeurs du sein (traitement médicamenteux)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cyclophosphamide</term><term>Fluorouracil</term><term>Mitoxantrone</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cyclophosphamide</term><term>Fluorouracil</term><term>Mitoxantrone</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords 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Adjuvant</term><term>Female</term><term>Humans</term><term>Mastectomy, Segmental</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local</term><term>Prospective Studies</term><term>Radiotherapy Dosage</term><term>Skin Pigmentation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Dosimétrie en radiothérapie</term><term>Femelle</term><term>Humains</term><term>Mastectomie partielle</term><term>Pigmentation de la peau</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Traitement médicamenteux adjuvant</term><term>Tumeurs du sein</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Azria, David" sort="Azria, David" uniqKey="Azria D" first="David" last="Azria">David Azria</name><name sortKey="Body, Gilles" sort="Body, Gilles" uniqKey="Body G" first="Gilles" last="Body">Gilles Body</name><name sortKey="Bosset, Jean Francois" sort="Bosset, Jean Francois" uniqKey="Bosset J" first="Jean-Francois" last="Bosset">Jean-Francois Bosset</name><name sortKey="Breteau, Noel" sort="Breteau, Noel" uniqKey="Breteau N" first="Noel" last="Breteau">Noel Breteau</name><name sortKey="Calais, Gilles" sort="Calais, Gilles" uniqKey="Calais G" first="Gilles" last="Calais">Gilles Calais</name><name sortKey="Fourquet, Alain" sort="Fourquet, Alain" uniqKey="Fourquet A" first="Alain" last="Fourquet">Alain Fourquet</name><name sortKey="Garaud, Pascal" sort="Garaud, Pascal" uniqKey="Garaud P" first="Pascal" last="Garaud">Pascal Garaud</name><name sortKey="Le Floch, Olivier" sort="Le Floch, Olivier" uniqKey="Le Floch O" first="Olivier" last="Le Floch">Olivier Le Floch</name><name sortKey="Serin, Daniel" sort="Serin, Daniel" uniqKey="Serin D" first="Daniel" last="Serin">Daniel Serin</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Toledano, Alain" sort="Toledano, Alain" uniqKey="Toledano A" first="Alain" last="Toledano">Alain Toledano</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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